Colon Cancer Screening

Research Article on Colon Cancer and Exercise

The CHALLENGE trial, led by the National Cancer Institute of Canada Clinical Trials Group, is a randomized controlled study investigating whether a structured physical activity (PA) program improves outcomes in survivors of high-risk stage II or III colon cancer. Following adjuvant therapy, 962 participants will be assigned to either a supervised PA intervention with behavioral support or general health education. The trial’s primary endpoint is disease-free survival, with secondary outcomes including patient-reported measures, physical functioning, biological markers, and cost-effectiveness. This trial aims to provide causal evidence on the benefits of PA in colon cancer survivorship and inform future healthcare policy. The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials Group - PubMed

Risk Factors

Age : Most people diagnosed with colon cancer are older than 50. Race : Black individuals in the U.S. are at a higher risk compared to other racial groups. Personal history : If someone has had colon cancer or polyps before, their risk of developing colon cancer again is higher. Inflammatory bowel diseases : Conditions like Crohn’s disease and ulcerative colitis, which cause inflammation of the intestines, increase colon cancer risk. Inherited syndromes : Genetic conditions like familial adenomatous polyposis and Lynch syndrome can increase the likelihood of colon cancer running in families. Family history : Having a blood relative with colon cancer, especially multiple family members, raises the risk. Diet : A diet low in fiber and high in fat, typical of many Western diets, might be linked to colon cancer. Diets with large amounts of red and processed meats could increase the risk. Lack of exercise : A sedentary lifestyle can increase the risk of colon cancer, while regular physical ...

Colon Cancer

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