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Research Article on Colon Cancer and Exercise

The CHALLENGE trial, led by the National Cancer Institute of Canada Clinical Trials Group, is a

randomized controlled study investigating whether a structured physical activity (PA) program improves outcomes

in survivors of high-risk stage II or III colon cancer. Following adjuvant therapy, 962 participants will be assigned

to either a supervised PA intervention with behavioral support or general health education. The trial’s primary

endpoint is disease-free survival, with secondary outcomes including patient-reported measures, physical

functioning, biological markers, and cost-effectiveness. This trial aims to provide causal evidence on the

benefits of PA in colon cancer survivorship and inform future healthcare policy. 


The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of

Canada Clinical Trials Group - PubMed








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