Colon cancer, or colorectal cancer, originates from polyps (growths) in the inner lining of the colon. If not addressed, it can metastasize to other parts of the body. The colon, also known as the large intestine, is responsible for extracting water and salt from solid waste. The majority of colon cancers are adenocarcinomas, which arise from the glands that line the colon's interior. Depending on its starting point, the cancer may be referred to as either colon or rectal cancer.
The CHALLENGE trial, led by the National Cancer Institute of Canada Clinical Trials Group, is a randomized controlled study investigating whether a structured physical activity (PA) program improves outcomes in survivors of high-risk stage II or III colon cancer. Following adjuvant therapy, 962 participants will be assigned to either a supervised PA intervention with behavioral support or general health education. The trial’s primary endpoint is disease-free survival, with secondary outcomes including patient-reported measures, physical functioning, biological markers, and cost-effectiveness. This trial aims to provide causal evidence on the benefits of PA in colon cancer survivorship and inform future healthcare policy. The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials Group - PubMed
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