Unexplained weight loss; On going discomfort in the stomach area, such as cramps, gas or pain; Change in bowel movement; Blood in stool
The CHALLENGE trial, led by the National Cancer Institute of Canada Clinical Trials Group, is a randomized controlled study investigating whether a structured physical activity (PA) program improves outcomes in survivors of high-risk stage II or III colon cancer. Following adjuvant therapy, 962 participants will be assigned to either a supervised PA intervention with behavioral support or general health education. The trial’s primary endpoint is disease-free survival, with secondary outcomes including patient-reported measures, physical functioning, biological markers, and cost-effectiveness. This trial aims to provide causal evidence on the benefits of PA in colon cancer survivorship and inform future healthcare policy. The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials Group - PubMed
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